黑腹果蝇 MDH 多态性：I. 实验室种群中的选择和 hitch-hiking。

MDH-polymorphism in Drosophila subobscura: I. Selection and hitch-hiking in laboratory populations.

机构信息

Institut für Biologie II, Lehrstuhl Populationsgenetik, Universität Tübingen, Germany.

出版信息

Theor Appl Genet. 1981 Mar;60(2):107-12. doi: 10.1007/BF00282426.

Abstract

The interrelation of genic polymorphism at the Malate dehydrogenase (Mdh)-locus and chromosomal polymorphism for superimposed gene arrangements was studied in 5 experimental populations of Drosophila subobscura. It could be shown that chromosomal polymorphism is maintained by balancing selection in favour of the heterozygotes. In contrast, selection at the Mdh-locus itself seems to be of minor importance. The changes of frequency observed for the Mdh-alleles are most probably due to hitch-hiking on the gene blocks enclosed by the chromosomal structures or to selection for tightly linked genes rather than to fitness differences between Mdh-genotypes. The results may be considered as a model for the situation found in natural populations of D. subobscura.

摘要

在 5 个实验种群的暗果蝇（Drosophila subobscura）中，研究了苹果酸脱氢酶（Mdh）基因座的基因多态性与叠加基因排列的染色体多态性之间的相互关系。结果表明，染色体多态性是由有利于杂合体的平衡选择维持的。相比之下，Mdh 基因座本身的选择似乎不太重要。观察到的 Mdh 等位基因频率的变化很可能是由于染色体结构所包含的基因块的 hitch-hiking 或紧密连锁基因的选择所致，而不是 Mdh 基因型之间的适应度差异。这些结果可以被认为是暗果蝇自然种群中发现的情况的一个模型。