自然存在的葡糖苷基黄烷酮芒果苷对大鼠生殖功能的影响。

Effect of mangiferin, a naturally occurring glucosylxanthone, on reproductive function of rats.

机构信息

Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, India.

出版信息

Pharm Res. 1984 Nov;1(6):279-82. doi: 10.1023/A:1016306304849.

Abstract

Female albino rats, treated with mangiferin at daily doses of 5 mg/100 g ip for 3 days during mid-gestation, showed complete fetal resorption. Administration of a mangiferin-Cu(2+) (1:1) complex, along with mangiferin, attenuated the effect of mangiferin and restored the completion of gestation in 60% of the rats. The mother rats that completed gestation successfully did not show any post-natal abnormality, and the litters born were also normal. Mangiferin treatment of non-gestating female rats caused little or no changes in their organ weights. However, changes in the protein and protein-DNA ratios of several organs were statistically significant. Mangiferin also modified the ascorbic acid retention capacity of adrenal glands of male rats in vitro. These findings are appraised in view of mangiferin as a potential antifertility agent.

摘要

在妊娠中期，每天给雌性白化大鼠腹腔内注射 5mg/100g 的芒果苷，连续 3 天，结果显示所有胎儿完全被吸收。同时给予芒果苷-Cu(2+)（1:1）络合物，可以减轻芒果苷的作用，并使 60%的大鼠成功完成妊娠。成功完成妊娠的母鼠在产后没有表现出任何异常，所生的幼崽也正常。芒果苷处理未妊娠的雌性大鼠，对其器官重量几乎没有影响或没有影响。然而，几种器官的蛋白质和蛋白质-DNA 比值发生了统计学意义上的变化。芒果苷还改变了雄性大鼠肾上腺的抗坏血酸保留能力。这些发现与芒果苷作为一种潜在的抗生育剂的观点是一致的。