血管紧张素 II 型受体对心血管系统的特异性作用。
Angiotensin II type-2 receptor-specific effects on the cardiovascular system.
机构信息
Center of Clinical Pharmacology, third Xiangya hospital, Central South University, Changsha 410013, China;
出版信息
Cardiovasc Diagn Ther. 2012 Mar;2(1):56-62. doi: 10.3978/j.issn.2223-3652.2012.02.02.
Abstract
The renin-angiotensin system (RAS) is intricately involved in cardiovascular homeostasis. It is well known that angiotensin II, the key effector in RAS, contributes to a range of cardiovascular pathologies and diseases via angiotensin II type-1 receptor (AT1R) activation. However, the role of angiotensin II type-2 receptor (AT2R) regulation is less well understood. Recent studies describe the role of the AT2R on cardiovascular function in normal and pathologic conditions. The data describe an important role of AT2R in blood pressure regulation, cardiac hypertrophy and fibrosis, myocardial infarction and vascular homeostasis.
摘要
肾素-血管紧张素系统（RAS）在心血管稳态中起着错综复杂的作用。众所周知，血管紧张素 II 是 RAS 的关键效应物，通过血管紧张素 II 型 1 受体（AT1R）的激活，导致一系列心血管病理和疾病的发生。然而，血管紧张素 II 型 2 受体（AT2R）的调节作用却知之甚少。最近的研究描述了 AT2R 在正常和病理条件下对心血管功能的作用。这些数据描述了 AT2R 在血压调节、心肌肥厚和纤维化、心肌梗死和血管稳态中的重要作用。
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