Et4NI 催化醛和醇与铵盐的酰胺化反应。

Et4NI-catalyzed amidation of aldehydes and alcohols with ammonium salts.

机构信息

Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P.R. China.

出版信息

Org Biomol Chem. 2014 Jan 21;12(3):414-7. doi: 10.1039/c3ob42037j. Epub 2013 Nov 27.

DOI:10.1039/c3ob42037j

PMID:24284959

Abstract

An efficient method for the oxidative amidation of benzylic aldehydes or alcohols with ammonium salts has been developed for the synthesis of primary amides using Et4NI as the catalyst and tert-butyl hydroperoxide as the oxidant. This amidation reaction is operationally straightforward and provides primary amides in moderate to good yields under mild conditions.

摘要

一种高效的方法，用于通过氧化氨化苄基醛或醇与铵盐合成伯酰胺，使用 Et4NI 作为催化剂和叔丁基过氧化物作为氧化剂。该酰胺化反应操作简单，在温和条件下以中等至良好的收率提供伯酰胺。