Zittermann Armin, Ernst Jana B, Gummert Jan F, Börgermann Jochen
Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Centre North Rhine-Westphalia (NRW), Ruhr University Bochum, Georgstr. 11, 32545, Bad Oeynhausen, Germany,
Eur J Nutr. 2014;53(2):367-74. doi: 10.1007/s00394-013-0634-3. Epub 2013 Dec 1.
There is considerable variation in incremental circulating 25-hydroxyvitamin D (25OHD) levels on vitamin D supplements, even when similar age groups and identical vitamin D doses are compared. We therefore aimed to investigate the importance of body weight for the dose-response relation in circulating 25OHD.
We performed a systematic review of randomized placebo-controlled vitamin D supplementation trials in all age groups ≥10 years to clarify the influence of body weight and other parameters on incremental circulating 25OHD levels (difference between baseline and in-study values) in vitamin D-deficient and non-deficient individuals.
We included 144 cohorts from 94 independent studies, published from 1990 to November 2012, in our systematic review. There was a logarithmic association between vitamin D dose per kg body weight per day and increment in circulating 25OHD. In multivariable regression analysis, vitamin D dose per kg body weight per day could explain 34.5% of variation in circulating 25OHD. Additional significant predictors were type of supplement (vitamin D2 or vitamin D3), age, concomitant intake of calcium supplements and baseline 25OHD, explaining 9.8, 3.7, 2.4 and 1.9%, respectively, of the variation in circulating 25OHD.
This systematic review demonstrates that body weight is an important predictor of variation in circulating 25OHD in cohorts on vitamin D supplements. Our model provides an estimate of the daily vitamin D dose that is necessary for achieving adequate circulating 25OHD levels in vitamin D-insufficient or vitamin D-deficient individuals/cohorts with different body weights and ages.
即便比较的是相似年龄组且维生素D剂量相同的人群，维生素D补充剂使循环25-羟维生素D（25OHD）水平的增量仍存在相当大的差异。因此，我们旨在研究体重对循环25OHD剂量反应关系的重要性。
我们对所有年龄≥10岁的随机安慰剂对照维生素D补充试验进行了系统评价，以阐明体重及其他参数对维生素D缺乏和非缺乏个体循环25OHD水平增量（基线值与研究期间值之差）的影响。
我们的系统评价纳入了1990年至2012年11月发表的94项独立研究中的144个队列。每日每千克体重的维生素D剂量与循环25OHD增量之间存在对数关联。在多变量回归分析中，每日每千克体重的维生素D剂量可解释循环25OHD变化的34.5%。其他显著预测因素包括补充剂类型（维生素D2或维生素D3）、年龄、钙补充剂的同时摄入情况以及基线25OHD水平，它们分别解释了循环25OHD变化的9.8%、3.7%、2.4%和1.9%。
这项系统评价表明，体重是维生素D补充剂队列中循环25OHD变化的重要预测因素。我们的模型提供了一个每日维生素D剂量的估计值，该剂量对于不同体重和年龄的维生素D不足或缺乏的个体/队列达到足够的循环25OHD水平是必要的。
