β-辛氧基卟吩

β-Octamethoxyporphycenes.

机构信息

School of Chemistry and Advance Centre of Research in High Energy Materials (ACRHEM), University of Hyderabad , Hyderabad-500046, India.

出版信息

Org Lett. 2014 Jan 3;16(1):78-81. doi: 10.1021/ol403068j. Epub 2013 Dec 2.

DOI:10.1021/ol403068j

PMID:24295048

Abstract

Porphycene with eight methoxy substituents at its β-positions was synthesized for the first time in three steps from 3,4-dimethoxypyrrole. The presence of methoxy groups increases its hydrophilicity as evident from their increased solubility in methanol. Among its metallo-derivatives, the Pd(II)-complex displays efficient singlet oxygen quantum yield (73%) and hence can be a potentially good photosensitizer for photo-oxidation, DNA cleavage, and photodynamic therapy (PDT).

摘要

首次从 3,4-二甲氧基吡咯三步合成了β-位带有八个甲氧基取代基的卟吩。甲氧基的存在增加了其亲水性，这从其在甲醇中的溶解度增加可以明显看出。在其金属衍生物中，Pd(II)-配合物显示出高效的单线态氧量子产率（73%），因此可能是一种良好的光氧化、DNA 断裂和光动力治疗（PDT）的光敏剂。