根据 bla(OXA-40) 基因和流行病学暴发状态，在蜡螟（Galleria mellonella）宿主模型中临床鲍曼不动杆菌分离株的致病性。
Pathogenicity of clinical Acinetobacter baumannii isolates in a Galleria mellonella host model according to bla(OXA-40) gene and epidemiological outbreak status.
机构信息
Chicago State University, Chicago, Illinois, USA.
出版信息
Antimicrob Agents Chemother. 2014;58(2):1240-2. doi: 10.1128/AAC.02201-13. Epub 2013 Dec 2.
Abstract
Clinical studies have suggested that blaOXA-40-positive Acinetobacter baumannii isolates are associated with poor patient outcomes; however, reasons for unfavorable outcomes are difficult to discern in clinical studies. The objective of this study was to assess the virulence of carbapenem-resistant A. baumannii according to blaOXA-40 and epidemiological outbreak status in a Galleria mellonella model. Eight isolates of A. baumannii were studied. Nonoutbreak isolates and blaOXA-40-negative isolates more rapidly killed infected G. mellonella (P < 0.01).
摘要
临床研究表明，blaOXA-40 阳性鲍曼不动杆菌分离株与患者预后不良相关；然而，在临床研究中很难确定不良结局的原因。本研究的目的是在蜡螟模型中根据 blaOXA-40 和流行病学暴发状态评估碳青霉烯类耐药鲍曼不动杆菌的毒力。研究了 8 株鲍曼不动杆菌。非暴发分离株和 blaOXA-40 阴性分离株更迅速地杀死感染的蜡螟（P < 0.01）。
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