Shah Altaf Hussain, Manjunatha B S, Bindayel Naif A, Khounganian Rita
Department of Preventive Dental Sciences, Salman bin Abdulaziz University, AlKharj, Saudi Arabia.
BMJ Case Rep. 2013 Dec 5;2013:bcr2013010408. doi: 10.1136/bcr-2013-010408.
The 47,XYY syndrome is an aneuploidy (abnormal number) of sex chromosomes, where a human male receives an extra Y chromosome, making 47 chromosomes instead of the usual 46. Individuals with 47,XYY are usually physically normal and tend to be tall and thin. They are not at increased risk of mental retardation and cardiovascular diseases. They may have speech delay, hyperactivity and normal/decreased IQ level. Behavioural problems are not common in 47,XYY individuals. There have been reports that suggest the tooth-size increase in 47,XYY males is due to a direct genetic effect. The patient presented with multiple over-retained deciduous, unerupted permanent teeth and increased incidence of carious lesions may be attributed to decreased oral hygiene maintenance. The present article describes the medical and dental history along with the clinical management of oral health issues in an 18-year-old male patient with 47,XYY syndrome having normal physical structure and development.
47,XYY综合征是一种性染色体非整倍体(染色体数目异常)疾病,即人类男性多了一条Y染色体,染色体总数为47条,而非正常的46条。患有47,XYY综合征的个体通常身体正常,往往身材瘦高。他们患智力迟钝和心血管疾病的风险并未增加。他们可能存在语言发育迟缓、多动,智商水平正常或降低。行为问题在47,XYY个体中并不常见。有报告表明,47,XYY男性牙齿尺寸增大是由直接的遗传效应导致的。该患者有多颗乳牙滞留、恒牙未萌出以及龋损发生率增加的情况,这可能归因于口腔卫生维护不足。本文描述了一名身体结构和发育正常的18岁47,XYY综合征男性患者的病史和牙科病史,以及口腔健康问题的临床处理情况。