PDT Research Institute, School of Nano System Engineering, Inje University , 197 Injero, Gimhae, Gyeongnam 621-749, Republic of Korea.
Inorg Chem. 2014 Jan 6;53(1):3-5. doi: 10.1021/ic401729k. Epub 2013 Dec 9.
The 4:1 supramolecular complexed ionic salt between pyridinium chlorin and polyanionic α-SiMo12O40 exhibits significantly enhanced photodynamic activity against A549 cell lines because of increased singlet oxygen photogeneration through high cellular penetration and localization of the chlorin molecules on the ionic salt into the cancer cell. Confocal laser scanning microscopy images clearly represent a higher uptake and photodynamic effect of this supramolecular complex corresponding to the lower IC50 value compared to the free chlorin.
具有 4:1 摩尔比的卟啉吡啶阳离子与多阴离子 α-SiMo12O40 形成的超分子离子盐显著提高了光动力学活性，这是因为通过提高细胞通透性和将氯原子分子定位在离子盐上，增加了单线态氧的光生成，从而进入癌细胞。共聚焦激光扫描显微镜图像清楚地表明，与游离卟啉相比，这种超分子复合物具有更高的摄取和光动力效应，相应的 IC50 值更低。
