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利妥昔单抗成功辅助治疗一名因获得性抗干扰素-γ自身抗体导致播散性非结核分枝杆菌感染的患者。

Rituximab as successful adjunct treatment in a patient with disseminated nontuberculous mycobacterial infection due to acquired anti-interferon-γ autoantibody.

作者信息

Czaja Christopher A, Merkel Patricia A, Chan Edward D, Lenz Laurel L, Wolf Molly L, Alam Rafeul, Frankel Stephen K, Fischer Aryeh, Gogate Shaila, Perez-Velez Carlos M, Knight Vijaya

机构信息

Division of Mycobacterial and Respiratory Infections.

出版信息

Clin Infect Dis. 2014 Mar;58(6):e115-8. doi: 10.1093/cid/cit809. Epub 2013 Dec 11.

DOI:10.1093/cid/cit809
PMID:24336756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3935498/
Abstract

An acquired immune deficiency due to interferon gamma (IFN-γ) autoantibodies was diagnosed in a 78-year-old Japanese man with treatment-refractory disseminated nontuberculous mycobacterial infection. In addition to standard antimycobacterial therapy, he was successfully treated with rituximab to eliminate B cells and thereby the autoantibody. Subsequently, he obtained a sustained remission from infection.

摘要

一名78岁的日本男性被诊断出因干扰素γ（IFN-γ）自身抗体导致获得性免疫缺陷，该患者患有治疗难治性播散性非结核分枝杆菌感染。除了标准的抗分枝杆菌治疗外，他还成功接受了利妥昔单抗治疗，以消除B细胞从而消除自身抗体。随后，他的感染得到了持续缓解。

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Anti-CD20 (rituximab) therapy for anti-IFN-γ autoantibody-associated nontuberculous mycobacterial infection.抗-CD20（利妥昔单抗）治疗与抗 IFN-γ 自身抗体相关的非结核分枝杆菌感染。
Blood. 2012 Apr 26;119(17):3933-9. doi: 10.1182/blood-2011-12-395707. Epub 2012 Mar 8.
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