Khatoon Lubna, Jan Muhammad Ishtiaq, Khan Inam Ullah, Ullah Farhat, Malik Salman A
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,
Acta Parasitol. 2013 Dec;58(4):564-9. doi: 10.2478/s11686-013-0181-3. Epub 2013 Dec 13.
Malaria is wide spread in poor world and its burden has been assessed by the enumeration of malarial parasites in blood of patients. This study was designed to find a relationship between social structure, and spread of malaria in Khyber agency. The average parasite density was 2050 parasite/μl in Khyber Agency. Due to economic and social setup most of the people have habit of sleeping in open air thus playing role in high malaria prevalence and Plasmodium vivax remains the prevalent species. Genetic study performed on 110 Blood samples showed less genetic diversity for both Plasmodium vivax and Plasmodium falciparum. Eight alleles were distinguished both for Pvmsp 3α and Pvmsp 3β in total of 20 and 39 amplified samples of P. vivax respectively. Out of 17 samples amplified for P. falciparum 11 showed genotype K1 and 10 for MAD at Pfmsp-1 while 14 alleles were identified for 3D7/1C and two for FC27 of corresponding families of Pfmsp-2 gene. This shows that Plasmodium parasites are not genetically diverse in Khyber agency.
疟疾在贫困地区广泛传播，其负担已通过对患者血液中疟原虫的计数来评估。本研究旨在找出开伯尔部落机构的社会结构与疟疾传播之间的关系。开伯尔部落机构的平均寄生虫密度为每微升2050个寄生虫。由于经济和社会状况，大多数人有露天睡觉的习惯，这在高疟疾流行率中起了作用，间日疟原虫仍然是主要流行种类。对110份血样进行的基因研究表明，间日疟原虫和恶性疟原虫的遗传多样性都较低。在总共20份和39份间日疟原虫扩增样本中，分别鉴别出间日疟原虫Pvmsp 3α和Pvmsp 3β各8个等位基因。在17份恶性疟原虫扩增样本中，11份显示为K1基因型，10份在Pfmsp-1处显示为MAD基因型，而在Pfmsp-2基因相应家族的3D7/1C中鉴定出14个等位基因，在FC27中鉴定出2个等位基因。这表明开伯尔部落机构的疟原虫在基因上没有多样性。
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