铁和活性氧在细胞死亡中的作用。
The role of iron and reactive oxygen species in cell death.
机构信息
1] Department of Biological Sciences, Columbia University, New York, New York, USA. [2] Department of Biology, Stanford University, Stanford, California, USA.
1] Department of Biological Sciences, Columbia University, New York, New York, USA. [2] Department of Chemistry, Columbia University, New York, New York, USA. [3] Department of Systems Biology, Columbia University, New York, New York, USA. [4] Howard Hughes Medical Institute, Columbia University, New York, New York, USA.
出版信息
Nat Chem Biol. 2014 Jan;10(1):9-17. doi: 10.1038/nchembio.1416.
The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive oxygen species (ROS) are unavoidable in an oxygen-rich environment. Iron and ROS are increasingly recognized as important initiators and mediators of cell death in a variety of organisms and pathological situations. Here, we review recent discoveries regarding the mechanism by which iron and ROS participate in cell death. We describe the different roles of iron in triggering cell death, targets of iron-dependent ROS that mediate cell death and a new form of iron-dependent cell death termed ferroptosis. Recent advances in understanding the role of iron and ROS in cell death offer unexpected surprises and suggest new therapeutic avenues to treat cancer, organ damage and degenerative disease.
过渡金属铁是生命所必需的，但在富含氧气的环境中，铁催化的活性氧（ROS）不可避免地具有潜在毒性。铁和 ROS 越来越被认为是多种生物和病理情况下细胞死亡的重要启动子和介质。在这里，我们回顾了最近关于铁和 ROS 参与细胞死亡的机制的发现。我们描述了铁触发细胞死亡的不同作用，铁依赖性 ROS 介导细胞死亡的靶标以及一种新形式的铁依赖性细胞死亡，称为铁死亡。对铁和 ROS 在细胞死亡中的作用的理解的最新进展带来了意想不到的惊喜，并为治疗癌症、器官损伤和退行性疾病提供了新的治疗途径。
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