Centre for Cancer Biomedicine, Oslo University Hospital, Oslo, Norway;
Blood. 2014 Feb 13;123(7):1051-4. doi: 10.1182/blood-2013-07-512392. Epub 2013 Dec 19.
Transformation of follicular lymphoma (FL) to a more aggressive disease is associated with rapid progression and death. Existing molecular markers for transformation are few and their clinical impact is limited. Here, we report on a whole-genome study of DNA copy numbers and gene expression profiles in serial FL biopsies. We identified 698 genes with high correlation between gene expression and copy number, and the molecular network most enriched for these cis-associated genes. This network includes 14 cis-associated genes directly related to the nuclear factor κB (NF-κB) pathway. For each of these 14 genes, the correlated NF-κB target genes were identified and corresponding expression scores were defined. The scores for 6 of the cis-associated NFκB pathway genes (BTK, IGBP1, IRAK1, ROCK1, TMED7-TICAM2, and TRIM37) were significantly associated with transformation. The results suggest that genes regulating B-cell survival and activation are involved in transformation of FL.
滤泡性淋巴瘤（FL）向侵袭性更强疾病的转化与快速进展和死亡相关。目前用于转化的分子标志物较少，其临床影响也有限。在这里，我们报告了一项关于 FL 活检连续样本的全基因组 DNA 拷贝数和基因表达谱的研究。我们鉴定出了 698 个基因，这些基因的表达和拷贝数之间具有高度相关性，并且这些顺式相关基因最富集的分子网络。该网络包括 14 个与核因子 κB（NF-κB）通路直接相关的顺式相关基因。对于这 14 个基因中的每一个，都鉴定了相关的 NF-κB 靶基因，并定义了相应的表达评分。其中 6 个顺式相关 NFκB 通路基因（BTK、IGBP1、IRAK1、ROCK1、TMED7-TICAM2 和 TRIM37）的评分与转化显著相关。结果表明，调节 B 细胞存活和激活的基因参与了 FL 的转化。
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