甲状腺激素与肌腱：当前观点及未来展望。简要综述。
Thyroid hormones and tendon: current views and future perspectives. Concise review.
作者信息
Oliva Francesco, Berardi Anna C, Misiti Silvia, Maffulli Nicola
机构信息
Department of Orthopaedics and Traumatology, University of Rome "Tor Vergata" School of Medicine, Rome, Italy.
Department of Transfusion Medicine, Laboratory of Stem Cells, Spirito Santo Hospital, Pescara, Italy.
出版信息
Muscles Ligaments Tendons J. 2013 Aug 11;3(3):201-3.
Abstract
Thyroid hormones (THs) T3 and T4, play an essential role in the development and metabolism of many tissues and organs, and have profound metabolic effects in adult life. THs action is mediated mainly by the thyroid hormone receptor (TRs) which seem to be ubiquitous. To-date thyroid-associated disease are not thought to be related in tendinopathies and tendons tears. Recent study demonstrated the presence of TRs in tendons and their possible role in the proliferation and apoptosis of human tenocyte isolated from tendon. We review new discovery that revisit our current thinking on the tendon biology focusing on thyroid hormones (THs) T3 and T4, and their possible role on human tenocyte.
摘要
甲状腺激素（THs）中的T3和T4在许多组织和器官的发育及代谢中起着至关重要的作用，并且在成年期具有深远的代谢影响。THs的作用主要由似乎无处不在的甲状腺激素受体（TRs）介导。迄今为止，甲状腺相关疾病被认为与肌腱病和肌腱撕裂无关。最近的研究表明肌腱中存在TRs，以及它们在从肌腱分离出的人肌腱细胞的增殖和凋亡中可能发挥的作用。我们回顾了新的发现，这些发现重新审视了我们目前对肌腱生物学的认识，重点关注甲状腺激素（THs）中的T3和T4，以及它们对人肌腱细胞可能产生的作用。
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