LAIR-1（CD305）在类风湿关节炎患者 T 细胞和单核细胞/巨噬细胞中的作用。
The role of LAIR-1 (CD305) in T cells and monocytes/macrophages in patients with rheumatoid arthritis.
机构信息
Department of Physiology, Fourth Military Medical University, #17 Changle West Road, Xi'an 710032, China.
Department of Orthopedic, The Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, #157 Xiwu Road, Xi'an 710003, China.
出版信息
Cell Immunol. 2014 Jan;287(1):46-52. doi: 10.1016/j.cellimm.2013.12.005. Epub 2013 Dec 17.
The LAIR-1 receptor is expressed on a majority of mononuclear leukocytes. It is used as a biomarker when testing synovial fluid for evidence of rheumatoid arthritis (RA). The primary objective of this study was to measure T cell- and monocyte/macrophage-specific LAIR-1 expression in RA patients and compare this to LAIR-1 expression in osteoarthritis (OA) patients and healthy individuals. LAIR-1 expression was significantly decreased in circulating CD4(+) T cells in RA patients compared to both OA patients and healthy individuals. In contrast, LAIR-1 is high in CD14(+) monocytes and local CD68(+) macrophages in synovial tissues from RA patients. Upon stimulation with TNF-α, LAIR-1 expression decreased in T-helper (Th)1 and Th2 CD4(+) T cells from healthy donors. These results indicate that LAIR-1 may exert different functions on T cells and monocytes/macrophages and suggest that LAIR-1 may be a novel therapeutic target for the treatment of RA.
LAIR-1 受体表达于大多数单核白细胞上。在检测滑液中是否存在类风湿关节炎 (RA) 的证据时，它被用作生物标志物。本研究的主要目的是测量 RA 患者 T 细胞和单核细胞/巨噬细胞特异性 LAIR-1 表达，并将其与骨关节炎 (OA) 患者和健康个体的 LAIR-1 表达进行比较。与 OA 患者和健康个体相比，RA 患者循环 CD4(+) T 细胞中的 LAIR-1 表达显著降低。相比之下，RA 患者滑膜组织中的 CD14(+)单核细胞和局部 CD68(+)巨噬细胞中 LAIR-1 表达较高。在 TNF-α刺激下，来自健康供体的 Th1 和 Th2 CD4(+) T 细胞中的 LAIR-1 表达下降。这些结果表明，LAIR-1 可能在 T 细胞和单核细胞/巨噬细胞上发挥不同的功能，并表明 LAIR-1 可能是治疗 RA 的新的治疗靶点。
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