Chemistry Department, College of Science and Arts, Al-Rass, P.O. Box 53, Qassim University, Buraidah 51477, Saudi Arabia.
Molecules. 2014 Jan 14;19(1):911-24. doi: 10.3390/molecules19010911.
This paper presents the design of some novel 3-acetylcoumarin derivatives, based on minimal inhibitory concentration values (MICs) previously obtained against some microorganism cultures, Gram positive and negative bacteria and fungi. Some of these molecules exhibited antibacterial activity against S. aureus, comparable to that of the standard used (impinem). The in vitro antioxidant activities of the novel 3-acetylcoumarin oxadiazoles were assayed by the quantitative 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity method. The compounds 5c,d proved to be the most active, showing the highest capacity to deplete the DPPH radicals. Structure elucidation of the products has been accomplished on the basis of IR, 1H-NMR, 13C-NMR, NOESY and HMBC NMR data.
本文提出了一些新型 3-乙酰基香豆素衍生物的设计，这些设计基于先前针对一些微生物培养物、革兰氏阳性和阴性细菌和真菌获得的最小抑菌浓度 (MIC) 值。这些分子中的一些表现出对金黄色葡萄球菌的抗菌活性，与使用的标准药物（IMPENEM）相当。新型 3-乙酰基香豆素恶二唑的体外抗氧化活性通过定量 1,1-二苯基-2-苦基肼（DPPH）自由基清除活性方法进行测定。化合物 5c,d 被证明是最活跃的，表现出最高的清除 DPPH 自由基的能力。产物的结构解析是基于 IR、1H-NMR、13C-NMR、NOESY 和 HMBC NMR 数据完成的。
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