Starzyńska Teresa, Deptała Andrzej, Królicki Leszek, Kunikowska Jolanta, Londzin-Olesik Magdalena, Nasierowska-Guttmejer Anna, Ruchała Marek, Strzelczyk Janusz, Szawłowski Andrzej, Zgliczyński Wojciech, Kos-Kudła Beata
Division of Endocrinology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.
Endokrynol Pol. 2013;64(6):494-504. doi: 10.5603/EP.2013.0032.
Neuroendocrine neoplasms of the large intestine account for 20% of all neuroendocrine neoplasms (NENs) and are most commonly found in the rectum. The rate of detection of colorectal NENs is increasing, and this tendency will continue due to the widespread use of colonoscopy as a screening tool and the removal of all diagnosed lesions. This paper provides updated guidelines for the management of patients with colorectal NENs. Recent data on epidemiology, clinical characteristics, biochemical, and pathomorphological diagnosis as well as useful imaging techniques are presented. We look in detail at novel methods of treatment including endoscopic and surgical management, pharmacological and radioisotope therapy. We summarise monitoring of the treatment.
大肠神经内分泌肿瘤占所有神经内分泌肿瘤(NENs)的20%,最常见于直肠。结直肠NENs的检出率正在上升,由于结肠镜作为筛查工具的广泛使用以及所有诊断病变的切除,这种趋势将持续下去。本文提供了结直肠NENs患者管理的最新指南。介绍了关于流行病学、临床特征、生化和病理形态学诊断以及有用的成像技术的最新数据。我们详细探讨了包括内镜和手术管理、药物和放射性同位素治疗在内的新型治疗方法。我们总结了治疗的监测情况。