阿拉斯加原住民的原发性肝癌。1980 - 1985年。

Primary liver cancer in Alaskan natives. 1980-1985.

作者信息

Lanier A P, McMahon B J, Alberts S R, Popper H, Heyward W L

机构信息

Arctic Investigations Laboratory, Centers for Disease Control, Anchorage, AK 99501.

出版信息

Cancer. 1987 Oct 15;60(8):1915-20. doi: 10.1002/1097-0142(19871015)60:8<1915::aid-cncr2820600841>3.0.co;2-5.

DOI:10.1002/1097-0142(19871015)60:8<1915::aid-cncr2820600841>3.0.co;2-5

PMID:2443234

Abstract

The authors reviewed the cases of 19 Alaskan Natives (15 men, four women) with primary hepatocellular carcinoma (HCC) diagnosed during 1980-1985. Of these 19 patients, 16 were seropositive for hepatitis B surface antigen (HBsAg). Alpha-fetoprotein (AFP) was elevated in 15 patients (all were HBsAg positive). The patients ranged in age from 8 to 80 years old. Of the 19 patients, 16 were Eskimo, 13 of whom were Yupik. The annual age-adjusted (world standard) incidence of HCC for all Alaskan Natives was 9.3/100,000 for men and 2.2/100,000 for women. The tumor was resected in seven patients; six showed no recurrence of cancer 1 to 4 years after surgery. Histologic evaluation in 18 patients revealed trabecular type of HCC in 15 and acinar HCC in two others. In 16 specimens in which nontumorous liver could be studied, only six had evidence of cirrhosis; ten others showed variants of chronic persistent hepatitis.

摘要

作者回顾了1980年至1985年间确诊的19例阿拉斯加原住民原发性肝细胞癌（HCC）病例（15名男性，4名女性）。在这19例患者中，16例乙肝表面抗原（HBsAg）血清学呈阳性。15例患者甲胎蛋白（AFP）升高（均为HBsAg阳性）。患者年龄在8岁至80岁之间。19例患者中，16例为爱斯基摩人，其中13例为尤皮克人。所有阿拉斯加原住民经年龄调整（世界标准）后的HCC年发病率，男性为9.3/10万，女性为2.2/10万。7例患者的肿瘤进行了切除；6例在术后1至4年未出现癌症复发。18例患者的组织学评估显示，15例为小梁型HCC，另外2例为腺泡型HCC。在16份可对非肿瘤性肝脏进行研究的标本中，只有6份有肝硬化证据；另外10份显示为慢性持续性肝炎的变异型。