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听神经瘤治疗趋势:牛津颅底诊所20年回顾

Trends in acoustic neuroma management: a 20-year review of the oxford skull base clinic.

作者信息

Mackeith Samuel A C, Kerr Richard S, Milford Chris A

机构信息

Department of ENT, John Radcliffe Hospital, Oxford, United Kingdom.

Department of Neurosurgery, John Radcliffe Hospital, Oxford, United Kingdom.

出版信息

J Neurol Surg B Skull Base. 2013 Aug;74(4):194-200. doi: 10.1055/s-0033-1342919. Epub 2013 Apr 1.

Abstract

Objective To describe the change in the management of acoustic neuromas at one United Kingdom center over a 20-year period and to compare this with what is known regarding trends in practice on a national and international scale. Design, Setting, and Participants Data was collected prospectively on all patients attending the Oxford Skull Base Clinic between 1990 and 2009. Main Outcome Measures The proportion of patients managed initially by observation versus radiotherapy versus surgery was recorded for each year. Results Significantly more patients received radiation treatment (instead of surgery) between 2000 and 2009 when compared with 1990 to 1999. Compared with national audit data, the Oxford Skull Base Clinic treats a higher proportion of patients with radiotherapy and significantly lower proportion with surgery, though the trend nationally is toward more observation and radiotherapy and less surgery. Conclusion Surgery will remain crucial in the management of some patients with acoustic neuromas (usually those with the larger tumors where radiosurgery is recognized to be less appropriate), but using current trends to predict future practice would suggest that alternative nonmicrosurgical treatment may play an increasingly important role in the future.

摘要

目的 描述英国某中心在20年期间听神经瘤管理方式的变化,并将其与全国及国际范围内已知的实践趋势进行比较。设计、背景和参与者 前瞻性收集了1990年至2009年期间就诊于牛津颅底诊所的所有患者的数据。主要观察指标 记录每年初诊时采用观察、放疗或手术治疗的患者比例。结果 与1990年至1999年相比,2000年至2009年期间接受放射治疗(而非手术)的患者明显增多。与全国审计数据相比,牛津颅底诊所采用放疗治疗的患者比例更高,采用手术治疗的患者比例显著更低,尽管全国趋势是更多地采用观察和放疗,而减少手术治疗。结论 手术在某些听神经瘤患者(通常是那些肿瘤较大、公认不太适合进行放射外科手术的患者)的管理中仍将至关重要,但根据当前趋势预测未来实践表明,替代性非显微手术治疗可能在未来发挥越来越重要的作用。

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