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在对 80 岁以上人群进行腹主动脉瘤腔内修复术后,进行有限且定制化的随访似乎是合理的。

A limited and customized follow-up seems justified after endovascular abdominal aneurysm repair in octogenarians.

机构信息

Division of Vascular Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Division of Vascular Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

出版信息

J Vasc Surg. 2014 May;59(5):1232-40. doi: 10.1016/j.jvs.2013.11.070. Epub 2014 Jan 17.

Abstract

OBJECTIVE

The objective of this study was to determine whether long-term follow-up after endovascular aneurysm repair (EVAR) is justified in octogenarians.

METHODS

Between September 1996 and October 2011, all patients, including octogenarians, treated for an abdominal aortic aneurysm (AAA) by EVAR were included in a prospective database. Patients older than 80 years and with a nonruptured infrarenal aneurysm treated electively or urgently were included in the study (study group [SG]). Patients with ruptured aneurysms and patients who died during surgery or within the first postoperative month were excluded from further analysis. The control group (CG) consisted of patients younger than 80 years, matched for gender and AAA diameter. All patients were evaluated 4 to 8 weeks after EVAR and then annually thereafter. Follow-up data were complemented by review of the computerized hospital registry and charts and by contact of the patient's general practitioner or referring hospital. Primary outcomes were stent- or aneurysm-related complications and interventions. Secondary outcomes were additional surgical complications and patient survival.

RESULTS

A total number of 193 patients (SG, n = 97; CG, n = 96) were included for analysis. Median age was 80 years, and 88.6% were male. Median follow-up time was 33.6 months (interquartile range [IQR], 12.9-68.3). Stent- and procedure-related postoperative complications were comparable between groups (SG, 41.2%; CG, 39.6%; P = .82). Median time to complication was 2.3 months (IQR, 0.2-19.4) in the SG compared with 18.1 months (IQR, 6.8-50.5) in the CG. The 2-year complication-free survival rates were 58% (SG) and 60% (CG). Interventions were performed significantly less frequently in octogenarians (SG, 8.2%; CG, 19.8%; P < .05). Median time to intervention was 11.1 months (IQR, 2.0-31.0) in the SG compared with 54.3 months (IQR, 15.0-93.2) in the CG. The 2-year intervention-free survival rates were 90% (SG) and 92% (CG). During follow-up, 98 patients died (SG, n = 54; CG, n = 44); median time to death was 31.8 months (IQR, 13.3-66.0) in the SG compared with 44.4 months (IQR, 15.0-77.7) in the CG. One aneurysm-related death occurred in the CG. The 2- and 5-year survival rates were 71% and 32% for the SG compared with 77% and 66% for the CG (P < .05).

CONCLUSIONS

Because of the low incidence of secondary procedures and AAA-related deaths in octogenarians, long-term and frequent follow-up after EVAR seems questionable. An adapted and shortened follow-up seems warranted in this patient group.

摘要

目的

本研究旨在确定在 80 岁以上患者中行血管内动脉瘤修复术(EVAR)后进行长期随访是否合理。

方法

1996 年 9 月至 2011 年 10 月,所有接受 EVAR 治疗的腹主动脉瘤(AAA)患者,包括 80 岁以上的患者,均被纳入前瞻性数据库。本研究纳入了择期或紧急治疗的非破裂型肾下 AAA 且年龄大于 80 岁的患者(研究组 [SG])。排除破裂型动脉瘤患者和术中死亡或术后 1 个月内死亡的患者。对照组(CG)由年龄小于 80 岁、性别和 AAA 直径匹配的患者组成。所有患者均在 EVAR 后 4 至 8 周进行评估,然后每年进行一次评估。通过查阅计算机化医院病历和图表以及联系患者的全科医生或转诊医院来补充随访数据。主要结局为支架或动脉瘤相关并发症和干预措施。次要结局为其他手术并发症和患者生存情况。

结果

共纳入 193 例患者进行分析(SG,n = 97;CG,n = 96)。中位年龄为 80 岁,88.6%为男性。中位随访时间为 33.6 个月(四分位距 [IQR],12.9-68.3)。SG 和 CG 组的支架和手术相关术后并发症发生率相当(SG,41.2%;CG,39.6%;P =.82)。SG 组并发症中位发生时间为 2.3 个月(IQR,0.2-19.4),CG 组为 18.1 个月(IQR,6.8-50.5)。SG 和 CG 的 2 年无并发症生存率分别为 58%和 60%。SG 组介入治疗的频率明显低于 CG 组(SG,8.2%;CG,19.8%;P <.05)。SG 组的中位介入时间为 11.1 个月(IQR,2.0-31.0),CG 组为 54.3 个月(IQR,15.0-93.2)。SG 和 CG 的 2 年无介入生存率分别为 90%和 92%。随访期间,98 例患者死亡(SG,n = 54;CG,n = 44);SG 组的中位死亡时间为 31.8 个月(IQR,13.3-66.0),CG 组为 44.4 个月(IQR,15.0-77.7)。CG 组有 1 例动脉瘤相关死亡。SG 和 CG 的 2 年和 5 年生存率分别为 71%和 32%,77%和 66%(P <.05)。

结论

由于 80 岁以上患者中继发性手术和 AAA 相关死亡的发生率较低,EVAR 后进行长期和频繁随访似乎是不合理的。在这组患者中,采用适应性和缩短的随访可能是合理的。

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