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[癌症患者的味觉障碍]

[Taste disorders in cancer patients].

作者信息

Gonella Silvia

出版信息

Assist Inferm Ric. 2013 Oct-Dec;32(4):223-32. doi: 10.1702/1381.15360.

Abstract

Taste disorders in cancer patients. Introduction. Taste disorders are a relevant but often underestimated and under reported symptom in cancer patients. Taste disorders can be a consequence of the illness or its treatment, especially in head and neck cancer patients. Aims. To describe the physiologic mechanisms of taste disorders in cancer patients, their assessment and possible strategies for prevention and treatment. Methods. Literature review. Results. Taste disorders affect quality of life and may be responsible of the occurrence of food aversions with possible weight loss and malnutrition, associated to worst outcomes for toxicity and survival. In spite of the progresses in the last decade, the assessment of taste disorders is far from being satisfactory. In fact research focused on gastrointestinal consequences of illness and treatments, reserving only a marginal attention to taste disorders, in spite of their prevalence. The available knowledge of the mechanisms underlying the development of taste disorders in cancer patients are presented, together with assessment and treatment and prevention strategies. Discussion. Taste disorders are underreported and underestimated, in spite of their prevalence, especially in cancer patients, possibly for the wrong assumption that they cannot be treated. This may explain why they are often not reported by patients.

摘要

癌症患者的味觉障碍。引言。味觉障碍是癌症患者中一个相关但常被低估和报告不足的症状。味觉障碍可能是疾病本身或其治疗的结果,尤其是在头颈部癌症患者中。目的。描述癌症患者味觉障碍的生理机制、评估方法以及预防和治疗的可能策略。方法。文献综述。结果。味觉障碍会影响生活质量,可能导致食物厌恶的发生,进而可能出现体重减轻和营养不良,这与毒性和生存的更差结果相关。尽管在过去十年中有了进展,但对味觉障碍的评估仍远不能令人满意。事实上,研究主要集中在疾病和治疗的胃肠道后果上,尽管味觉障碍普遍存在,但对其关注甚少。本文介绍了癌症患者味觉障碍发生机制的现有知识,以及评估、治疗和预防策略。讨论。尽管味觉障碍普遍存在,但尤其是在癌症患者中,其报告不足且被低估,这可能是因为错误地认为它们无法治疗。这或许可以解释为什么患者常常不报告这些症状。

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