儿童和青少年慢性髓性白血病：来自印度东部的单中心经验
Chronic myeloid leukemia in children and adolescents: A single center experience from Eastern India.
作者信息
Raut Lalit, Bohara Vinay V, Ray Siddhartha S, Chakrabarti Prantar, Chaudhuri Utpal
机构信息
Institute of Hematology and Transfusion Medicine, Medical College and Hospital, Kolkata, West Bengal, India.
出版信息
South Asian J Cancer. 2013 Oct;2(4):260-4. doi: 10.4103/2278-330X.119891.
CONTEXT
Chronic Myeloid Leukemia (CML) constitutes around 3% of leukemia in the children and adolescent age group.
AIMS
The aim of the study was to evaluate the characteristics at presentation and the treatment outcome of CML in the children and adolescent age group.
SETTINGS AND DESIGN
Retrospective analysis was carried out at a single center in India.
MATERIALS AND METHODS
Thirteen patients (≤17 years) attending CML outdoor from April 2008 to August 2012 were included in the analysis.
STATISTICAL ANALYSIS USED
The mean and median of various parameters were calculated using a Microsoft excel sheet. SPSS 16.0 version software was used to calculate OS and PFS.
RESULTS
CML-CP was the most common phase at presentation. Maximum patients belonged to the 14 - 17 year old age group. Disease was common in the male sex. Splenic discomfort and asthenia were the most common symptoms and splenomegaly was the most common sign.
CONCLUSIONS
The treatment with Imatinib was effective and well-tolerated.
背景
慢性髓系白血病（CML）在儿童和青少年年龄组的白血病中约占3%。
目的
本研究的目的是评估儿童和青少年年龄组CML的发病特征及治疗结果。
地点和设计
在印度的一个单一中心进行回顾性分析。
材料和方法
分析纳入了2008年4月至2012年8月期间在CML门诊就诊的13例（≤17岁）患者。
所用统计分析方法
使用Microsoft excel工作表计算各种参数的均值和中位数。使用SPSS 16.0版软件计算总生存期（OS）和无进展生存期（PFS）。
结果
CML慢性期（CML-CP）是最常见的发病阶段。大多数患者属于14 - 17岁年龄组。该疾病在男性中更为常见。脾区不适和乏力是最常见的症状，脾肿大是最常见的体征。
结论
伊马替尼治疗有效且耐受性良好。
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