碳纳米管：药物递送应用的一个潜在概念。
Carbon nanotubes: a potential concept for drug delivery applications.
作者信息
Kumar Rakesh, Dhanawat Meenakshi, Kumar Sudhir, Singh Brahma N, Pandit Jayant K, Sinha Vivek R
机构信息
UIPS, Panjab University, Chandigarh 160014, India.
出版信息
Recent Pat Drug Deliv Formul. 2014 Apr;8(1):12-26. doi: 10.2174/1872211308666140124095745.
The unique properties of carbon nanotubes (CNTs) make them a highly interesting and demandable nanocarrier in the field of nanoscience. CNTs facilitate efficient delivery of therapeutics like drugs, proteins, genes, nucleic acids, vitamins and lot more. Even though highly beneficial, the biocompatibility of CNTs is a major issue in their questioning their potential application in targeting drug delivery. Studies confirmed subdued toxicity of CNTs following slight modifications like functionalization, controlled dimensions, purification etc. A well-established mechanism for cellular internalization is an insistent need to attain a more efficient and targeted delivery. Recent patents have been thoroughly discussed in the text below.
碳纳米管（CNTs）的独特性质使其成为纳米科学领域中极具吸引力且备受需求的纳米载体。碳纳米管有助于高效递送药物、蛋白质、基因、核酸、维生素等多种治疗剂。尽管碳纳米管非常有益，但其生物相容性是质疑其在靶向药物递送中潜在应用的一个主要问题。研究证实，经过功能化、尺寸控制、纯化等轻微修饰后，碳纳米管的毒性会降低。实现更高效、靶向递送迫切需要一种成熟的细胞内化机制。下文将对近期的专利进行全面讨论。
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