球蛋白超家族：在一氧化氮形成和衰减中的作用。
The globin superfamily: functions in nitric oxide formation and decay.
出版信息
Biol Chem. 2014 Jun;395(6):631-9. doi: 10.1515/hsz-2013-0289.
Abstract
Globin proteins are ubiquitous in living organisms and carry out a variety of functions related to the ability of their prosthetic heme group to bind gaseous ligands, such as oxygen, nitric oxide (NO), and CO. Moreover, they catalyze important reactions with nitrogen oxide species, such as NO dioxygenation and nitrite reduction. The formation of NO from nitrite is a reaction catalyzed by globins that has received increasing attention due to its potential as a hypoxic NO signaling mechanism. In this review, we revisit the current knowledge about the role of globins in NO formation and its physiological implications.
摘要
球蛋白在生物体中无处不在，它们通过其辅基血红素与气态配体（如氧气、一氧化氮（NO）和一氧化碳）结合的能力，执行着多种功能。此外，它们还能催化与氮氧化物种类有关的重要反应，如一氧化氮的双加氧作用和亚硝酸盐的还原。亚硝酸盐形成 NO 的反应是由球蛋白催化的，由于其作为缺氧诱导的 NO 信号机制的潜力，该反应受到了越来越多的关注。在这篇综述中，我们重新审视了球蛋白在 NO 形成中的作用及其生理意义的现有知识。
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