类囊体膜动力学的粗粒度计算机模拟：方法与机遇
Coarse-grained computer simulation of dynamics in thylakoid membranes: methods and opportunities.
作者信息
Schneider Anna R, Geissler Phillip L
机构信息
Biophysics Graduate Group, University of California Berkeley, CA, USA ; Department of Chemistry, University of California Berkeley, CA, USA.
Department of Chemistry, University of California Berkeley, CA, USA ; Chemical Sciences and Physical Biosciences Divisions, Lawrence Berkeley National Laboratory Berkeley, CA, USA.
出版信息
Front Plant Sci. 2014 Jan 21;4:555. doi: 10.3389/fpls.2013.00555. eCollection 2013.
Coarse-grained simulation is a powerful and well-established suite of computational methods for studying structure and dynamics in nanoscale biophysical systems. As our understanding of the plant photosynthetic apparatus has become increasingly nuanced, opportunities have arisen for coarse-grained simulation to complement experiment by testing hypotheses and making predictions. Here, we give an overview of best practices in coarse-grained simulation, with a focus on techniques and results that are applicable to the plant thylakoid membrane-protein system. We also discuss current research topics for which coarse-grained simulation has the potential to play a key role in advancing the field.
粗粒度模拟是一套功能强大且成熟的计算方法，用于研究纳米级生物物理系统中的结构和动力学。随着我们对植物光合装置的理解越来越细致入微，粗粒度模拟通过检验假设和进行预测来补充实验的机会也随之出现。在这里，我们概述了粗粒度模拟的最佳实践，重点关注适用于植物类囊体膜蛋白系统的技术和结果。我们还讨论了当前的研究课题，对于这些课题，粗粒度模拟有可能在推动该领域发展方面发挥关键作用。
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