阿那白滞素致弥漫性大 B 细胞淋巴瘤患者关节炎相关性间质性肉芽肿性皮炎恶化。

Exacerbation of interstitial granulomatous dermatitis with arthritis by anakinra in a patient with diffuse large B-cell lymphoma.

机构信息

Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Greece.

出版信息

Clin Exp Rheumatol. 2014 Mar-Apr;32(2):259-61. Epub 2014 Jan 30.

Abstract

Interstitial granulomatous dermatitis with arthritis (IGDA) is a rare idiopathic skin disorder with variable cutaneous expression, typically associated with a seronegative arthritis. Histopathology of this disorder reveals a granulomatous infiltrate with foci of collagen degeneration in the deep reticular dermis. We present a case of IGDA in a 56-year-old man with diffuse large B-cell lymphoma, exacerbated by the administration of anakinra.

摘要

间质性肉芽肿性皮炎伴关节炎（IGDA）是一种罕见的特发性皮肤疾病，具有多种皮肤表现，通常与血清阴性关节炎相关。该疾病的组织病理学显示，在深部网状真皮中有局灶性胶原变性的肉芽肿浸润。我们报告了一例 56 岁男性的 IGDA 病例，他患有弥漫性大 B 细胞淋巴瘤，在接受阿那白滞素治疗后病情加重。