miRNA423-5p 通过靶向胃癌细胞中的三叶因子 1 调节细胞增殖和侵袭。
miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.
机构信息
Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361004, Fujian Province, PR China.
Faculty of Clinical Medicine, Medical College of Xiamen University, Xiamen 361005, Fujian Province, PR China.
出版信息
Cancer Lett. 2014 May 28;347(1):98-104. doi: 10.1016/j.canlet.2014.01.024. Epub 2014 Jan 31.
TFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer.
TFF1 是 TFF 家族中的一种小分泌蛋白，作为上皮修复和细胞运动的促动力因子，以及在胃中作为肿瘤抑制基因发挥着关键作用。在这项研究中，我们鉴定出 TFF1 是 miRNA-423-5p 的一个新的靶基因。miRNA-423-5p 通过结合其 3'UTR 负调控 TFF1 的表达，并通过 TFF1 依赖的方式参与胃癌细胞的增殖/侵袭相关过程。我们的研究结果表明，miR-423-5p 可能成为未来针对胃癌特异性治疗干预的新靶点。
Zotero 插件