术中放疗作为早期乳腺癌的一种治疗方案。
Intraoperative radiotherapy as a protocol for the treatment of initial breast cancer.
作者信息
Bromberg Silvio Eduardo, Hanriot Rodrigo de Morais, Nazário Afonso Celso Pinto
出版信息
Einstein (Sao Paulo). 2013 Dec;11(4):439-45. doi: 10.1590/s1679-45082013000400006.
OBJECTIVE
To report on preliminary outcomes of single-dose intraoperative radiotherapy for early-stage breast cancer based on local recurrence rates and complications.
METHODS
Fifty postmenopausal women with <2.5cm breast tumors and clinically normal axillary lymph nodes were submitted to quadrantectomy, sentinel lymph node biopsy and intraoperative radiotherapy and studied. Mean follow-up time was 52.1 months.
RESULTS
Mean patient age was 65.5 years; mean tumor diameter was 1.41cm 82% of nodules were hormonal receptor positive and HER-2 negative. All patients received a 21 Gy radiation dose for a mean time of 8.97 minutes. Distant metastases were not observed. Local recurrence was documented in three cases, with identical histological diagnosis as the primary tumors. Thirty-five (70%) patients had local fibrosis, with gradual improvement and complete resolution over 18 months. Postoperative infection and seroma formation were not observed.
CONCLUSION
Partial radiotherapy is a potentially feasible and promising technique. Careful patient selection is recommended before a longer follow-up period has elapsed to confirm intraoperative radiotherapy safety and efficacy.
目的
基于局部复发率和并发症报告早期乳腺癌单剂量术中放疗的初步结果。
方法
对50例绝经后乳腺肿瘤<2.5cm且腋窝淋巴结临床正常的女性进行象限切除术、前哨淋巴结活检和术中放疗并进行研究。平均随访时间为52.1个月。
结果
患者平均年龄为65.5岁；平均肿瘤直径为1.41cm，82%的结节激素受体阳性且HER-2阴性。所有患者均接受21Gy的放射剂量，平均时间为8.97分钟。未观察到远处转移。3例出现局部复发，组织学诊断与原发肿瘤相同。35例（70%）患者出现局部纤维化，18个月内逐渐改善并完全消退。未观察到术后感染和血清肿形成。
结论
局部放疗是一种潜在可行且有前景的技术。在更长随访期以确认术中放疗安全性和有效性之前，建议谨慎选择患者。
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