Dong W, Chochua S, McGee L, Jackson D, Klugman K P, Vidal J E
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Antimicrob Agents Chemother. 2014;58(4):2459-62. doi: 10.1128/AAC.02630-13. Epub 2014 Feb 3.
Three invasive Streptococcus pneumoniae strains nonsusceptible to linezolid were isolated in the United States between 2001 and 2012 from the CDC's Active Bacterial Core surveillance. Linezolid binds ribosomal proteins where structural changes within its target site may confer resistance. Our study identified mutations and deletions near the linezolid binding pocket of two of these strains within the rplD gene, which encodes ribosomal protein L4. Mutations in the 23S rRNA alleles or the rplV gene were not detected.
2001年至2012年间,在美国疾病控制与预防中心的主动细菌核心监测中,分离出了三株对利奈唑胺不敏感的侵袭性肺炎链球菌菌株。利奈唑胺与核糖体蛋白结合,其靶位点内的结构变化可能导致耐药性。我们的研究在编码核糖体蛋白L4的rplD基因中,确定了其中两株菌株利奈唑胺结合口袋附近的突变和缺失。未检测到23S rRNA等位基因或rplV基因中的突变。