钴催化烯烃与频哪醇硼烷的氢硼化反应。
A cobalt-catalyzed alkene hydroboration with pinacolborane.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032 (China).
出版信息
Angew Chem Int Ed Engl. 2014 Mar 3;53(10):2696-700. doi: 10.1002/anie.201310096. Epub 2014 Feb 3.
An extremely efficient cobalt catalyst for the hydroboration of both vinylarenes and aliphatic α-olefins with pinacolborane is described, providing the anti-Markovnikov products with excellent regio- and chemoselectivity, broad functional-group tolerance, and high turnover numbers (up to 19,800). The alkene hydroboration route is further extended to a two-step, one-pot hydroboration and cross-coupling of alkylboronates with aryl chlorides.
本文描述了一种高效的钴催化剂，可用于对烯基芳烃和脂肪族α-烯烃进行硼氢化反应，所用硼烷试剂为频哪醇硼烷，可得到区域和化学选择性优异、官能团容忍性好、催化剂用量高（高达 19800）的反马氏加成产物。烯烃硼氢化反应路线可进一步扩展为两步一锅法反应，即烷基硼酸酯与芳基氯的硼氢化和交叉偶联反应。
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