Department of Cardiovascular Medicine, Institute of Biomedical & Health Sciencies, Hiroshima University.
Circ J. 2014;78(4):950-4. doi: 10.1253/circj.cj-13-1330. Epub 2014 Feb 5.
Poor oral health is an independent predictor of cardiovascular outcome. Endothelial dysfunction is the initial step of atherosclerosis, resulting in cardiovascular outcomes; but there is no information on the association between oral health and endothelial function. The purpose of this study was to determine the relationships between oral health and endothelial function.
A total of 190 subjects who underwent health examinations (mean age, 57±18 years), including patients with cardiovascular disease, completed a questionnaire on oral health and frequency of tooth brushing, and underwent measurement of vascular function, flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation. The subjects were divided into 2 groups according to frequency of tooth brushing (≥twice/day and <once/day). FMD was significantly lower in the <once/day tooth brushing group as compared to the ≥twice/day tooth brushing group (3.3±2.2% vs. 5.0±3.0%, P<0.001). There was no significant difference in nitroglycerine-induced vasodilation between the 2 groups. On multiple logistic regression analysis, tooth brushing <once/day remained independently associated with low FMD tertile.
Poor oral health, that is, decreased frequency of tooth brushing, is associated with endothelial dysfunction.
口腔健康状况不佳是心血管结局的独立预测因子。内皮功能障碍是动脉粥样硬化的初始步骤，导致心血管结局；但目前尚不清楚口腔健康与内皮功能之间的关系。本研究旨在确定口腔健康与内皮功能之间的关系。
共有 190 名接受健康检查的受试者（平均年龄 57±18 岁），包括心血管疾病患者，他们完成了口腔健康和刷牙频率的问卷，并进行了血管功能、血流介导的血管扩张（FMD）和硝酸甘油诱导的血管扩张测量。根据刷牙频率（≥每日两次和<每日一次）将受试者分为两组。与每日刷牙≥两次的组相比，每日刷牙<一次的组 FMD 明显较低（3.3±2.2% vs. 5.0±3.0%，P<0.001）。两组间硝酸甘油诱导的血管扩张无显著差异。多因素逻辑回归分析显示，每日刷牙<一次与 FMD 三分位较低独立相关。
口腔健康状况较差，即刷牙频率降低，与内皮功能障碍有关。
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