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[晚期膀胱尿路上皮癌的医学治疗现状]

[Current developments in the medical treatment of advanced urothelial carcinoma of the bladder].

作者信息

Schmid S C, Gschwend J E, Retz M

机构信息

Urologische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München.

出版信息

Aktuelle Urol. 2014 Jan;45(1):55-63; quiz 64-5. doi: 10.1055/s-0033-1360281. Epub 2014 Feb 5.

Abstract

Medical treatment of advanced urothelial carcinoma of the bladder consists of perioperative treatments as well as palliative chemotherapy in advanced stages. This article focuses on important clinical trials and developments of the last two years, with a review of literature and proceedings of the relevant meetings (ASCO, GU-ASCO, EAU, AUA). The general benefit of perioperative chemotherapy is confirmed. Chemotherapy with Gemcitabin/Cisplatin remains the therapy of choice in the palliative setting. So far, targeted therapies did not show convincing results.

摘要

晚期膀胱尿路上皮癌的医学治疗包括围手术期治疗以及晚期的姑息化疗。本文重点关注过去两年的重要临床试验和进展,并对相关会议(美国临床肿瘤学会、泌尿生殖系统肿瘤研讨会、欧洲泌尿外科学会、美国泌尿外科学会)的文献和会议记录进行综述。围手术期化疗的总体益处得到了证实。吉西他滨/顺铂化疗仍是姑息治疗中的首选疗法。到目前为止,靶向治疗尚未显示出令人信服的结果。

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