出生时低浓度的HIV-1 DNA会延迟诊断，使确定接受抗逆转录病毒治疗以潜在预防病毒库建立的婴儿变得复杂。
Low concentrations of HIV-1 DNA at birth delays diagnosis, complicating identification of infants for antiretroviral therapy to potentially prevent the establishment of viral reservoirs.
作者信息
Mitchell Caroline, Dross Sandra, Beck Ingrid A, Micek Mark A, Frenkel Lisa M
机构信息
University of Washington.
出版信息
Clin Infect Dis. 2014 Apr;58(8):1190-3. doi: 10.1093/cid/ciu068. Epub 2014 Feb 5.
Abstract
Among infants exposed to human immunodeficiency virus type 1 (HIV-1), detection of viral infection at birth was increased by 39% (95% confidence interval, 19%-47%) by increasing DNA input from dried blood spots into polymerase chain reaction. Infants with low concentrations of HIV-1 at birth may be the best target population to evaluate whether immediate antiretroviral therapy can prevent long-term infection.
摘要
在暴露于1型人类免疫缺陷病毒（HIV-1）的婴儿中，通过增加干血斑中用于聚合酶链反应的DNA输入量，出生时病毒感染的检测率提高了39%（95%置信区间，19%-47%）。出生时HIV-1浓度较低的婴儿可能是评估立即进行抗逆转录病毒治疗是否能预防长期感染的最佳目标人群。
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本文引用的文献
1
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N Engl J Med. 2013 Nov 7;369(19):1828-35. doi: 10.1056/NEJMoa1302976. Epub 2013 Oct 23.
2
Highly precise measurement of HIV DNA by droplet digital PCR.通过液滴数字 PCR 进行高度精确的 HIV DNA 测量。
PLoS One. 2013;8(4):e55943. doi: 10.1371/journal.pone.0055943. Epub 2013 Apr 3.
3
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study.早期启动抗逆转录病毒治疗中断后实现长期病毒学缓解的治疗后HIV-1控制者：ANRS VISCONTI研究
PLoS Pathog. 2013 Mar;9(3):e1003211. doi: 10.1371/journal.ppat.1003211. Epub 2013 Mar 14.
4
Early diagnosis of in utero and intrapartum HIV infection in infants prior to 6 weeks of age.在婴儿出生后 6 周之前，对宫内和产时 HIV 感染进行早期诊断。
J Clin Microbiol. 2012 Jul;50(7):2373-7. doi: 10.1128/JCM.00431-12. Epub 2012 Apr 18.
5
Nevirapine resistance by timing of HIV type 1 infection in infants treated with single-dose nevirapine.单剂量奈韦拉平治疗婴儿时，HIV-1 感染时间与奈韦拉平耐药的关系。
Clin Infect Dis. 2010 May 15;50(10):1405-14. doi: 10.1086/652151.
6
Detection of low levels of human immunodeficiency virus (HIV) may be critical for early diagnosis of pediatric HIV infection by use of dried blood spots.检测低水平的人类免疫缺陷病毒（HIV）对于通过干血斑早期诊断儿童HIV感染可能至关重要。
J Clin Microbiol. 2009 Sep;47(9):2989-91. doi: 10.1128/JCM.02453-08. Epub 2009 Jul 22.
7
Quantitative RNA testing for diagnosis of HIV-infected infants.
J Acquir Immune Defic Syndr. 2003 Feb 1;32(2):192-5. doi: 10.1097/00126334-200302010-00011.
8
Understanding the timing of HIV transmission from mother to infant.了解艾滋病毒从母亲传播给婴儿的时间。
JAMA. 2001 Feb 14;285(6):709-12. doi: 10.1001/jama.285.6.709.
9
Simple, sensitive, and specific detection of human immunodeficiency virus type 1 subtype B DNA in dried blood samples for diagnosis in infants in the field.用于现场婴儿诊断的干血样本中1型人类免疫缺陷病毒B亚型DNA的简单、灵敏且特异的检测
J Clin Microbiol. 2001 Jan;39(1):29-33. doi: 10.1128/JCM.39.1.29-33.2001.
10
Defining the time of fetal or perinatal acquisition of human immunodeficiency virus type 1 infection on the basis of age at first positive culture. Women and Infants Transmission Study (WITS).
J Infect Dis. 1997 Mar;175(3):712-5. doi: 10.1093/infdis/175.3.712.
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