Miyake Yasufumi
Emergency and Critical Care Medicine, Showa University School of Medicine.
Brain Nerve. 2014 Feb;66(2):97-105.
The morbidity of hyperglycemic crises and acute hypoglycemic attacks in patients with diabetes mellitus has been increasing for the past several decades. One of the reasons for this is the increase in the number of patients with diabetes. The increased proportion of aging and isolation in society is another reason. The author has discussed patients with these complaints: their epidemiology, pathophysiology, and management in the emergency department. Hyperglycemic crises include diabetic ketoacidosis (DKA), hyperosmolar hyperglycemic syndrome (HHS), and lactic acidosis (LA). Younger patients with type 1 diabetes suffer from DKA; inappropriate insulin therapy or infection is usually the trigger. Older patients with type 2 diabetes are at risk of HHS in the course of sepsis or in the perioperative period. The treatment of both types of patients is common. Sufficient amount of intravenous extracellular fluid and constant infusion of insulin are essential. The development of LA is not associated with the use of metformin, but with the severity of the pre-existing disease. Early recognition and aggressive treatment is vital to improving the prognosis of hyperglycemic emergencies and severe hypoglycemic episodes.
在过去几十年中,糖尿病患者高血糖危象和急性低血糖发作的发病率一直在上升。原因之一是糖尿病患者数量的增加。社会中老龄化和独居比例的上升是另一个原因。作者讨论了有这些病症的患者:他们在急诊科的流行病学、病理生理学及管理。高血糖危象包括糖尿病酮症酸中毒(DKA)、高渗高血糖综合征(HHS)和乳酸性酸中毒(LA)。1型糖尿病的年轻患者易患DKA;通常由不适当的胰岛素治疗或感染引发。2型糖尿病的老年患者在脓毒症过程中或围手术期有发生HHS的风险。这两类患者的治疗有共同之处。充足的静脉输注细胞外液和持续输注胰岛素至关重要。LA的发生与二甲双胍的使用无关,而是与原有疾病的严重程度有关。早期识别和积极治疗对于改善高血糖急症和严重低血糖发作的预后至关重要。