盐酸兰地洛尔在非体外循环冠状动脉搭桥术后的作用
Effect of landiolol hydrochloride after off-pump coronary artery bypass.
作者信息
Maisawa Kazuma, Yamazaki Kenji, Ishitoya Hiroshi, Shimamura Yoshiei
机构信息
Department of Cardiovascular Surgery, Saitama City Hospital, Saitama City, Saitama, Japan.
出版信息
Asian Cardiovasc Thorac Ann. 2013 Apr;21(2):170-5. doi: 10.1177/0218492312450865.
OBJECTIVES
many studies have shown that oral beta blockers reduce the incidence of atrial fibrillation after coronary artery bypass. The goal of this study was to determine whether landiolol, an intravenous beta blocker, reduces the incidence of atrial fibrillation after off-pump coronary artery bypass.
METHODS
39 consecutive patients were given landiolol after coronary artery bypass, and 20 who were not given landiolol served as a control group. Landiolol was intravenously administered at 1 µg.kg(-1).min(-1) in the intensive care unit.
RESULTS
the mean dose of landiolol was 2.3 ± 1.2 1 µg.kg(-1).min(-1). The incidence of atrial fibrillation during intensive care unit stay was significantly lower in the landiolol group compared to the control group: 2.6% (1/39) vs. 20% (4/20). Heart rate after landiolol administration was significantly lower than that before administration, whereas landiolol had no effect on blood pressure. C-reactive protein and creatine kinase levels 7 days after surgery were significantly lower in the landiolol group.
CONCLUSION
continuous administration of landiolol at a low dose after off-pump coronary artery bypass reduced the incidence of atrial fibrillation.
目的
许多研究表明口服β受体阻滞剂可降低冠状动脉搭桥术后房颤的发生率。本研究的目的是确定静脉用β受体阻滞剂兰地洛尔是否能降低非体外循环冠状动脉搭桥术后房颤的发生率。
方法
39例连续患者在冠状动脉搭桥术后给予兰地洛尔，20例未给予兰地洛尔的患者作为对照组。在重症监护病房以1μg·kg⁻¹·min⁻¹的剂量静脉注射兰地洛尔。
结果
兰地洛尔的平均剂量为2.3±1.2μg·kg⁻¹·min⁻¹。与对照组相比，兰地洛尔组在重症监护病房停留期间房颤的发生率显著降低：2.6%（1/39）对20%（4/20）。给予兰地洛尔后心率显著低于给药前，而兰地洛尔对血压无影响。兰地洛尔组术后7天的C反应蛋白和肌酸激酶水平显著较低。
结论
非体外循环冠状动脉搭桥术后持续低剂量应用兰地洛尔可降低房颤的发生率。
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