多发性骨髓瘤患者的血小板功能紊乱

Disturbances of platelet function in patients with multiple myeloma.

作者信息

Czestochowska E, Tymiński W, Górski J, Umiastowski J

机构信息

IV Clinic of Internal Medicine, Medical Academy in Gdańsk, Poland.

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(6):845-51.

PMID:2453414

Abstract

Coagulation disturbances in patients with multiple myeloma are presented. Platelet disfunction was especially observed, but only in patients with marked hyperproteinemia and a high level of immunoglobulins in plasma, whereas normal adhesion and aggregation were noticed in 3 out of 17 patients without protein disturbances. Chemotherapy as well as plasma exchange caused not only a decrease of the paraprotein level in plasma, but also a normalization of the failure previously observed in platelet function. Our experiments confirm the opinion that protein M in plasma is responsible for the disturbances observed in multiple myeloma.

摘要

本文介绍了多发性骨髓瘤患者的凝血功能紊乱情况。特别观察到血小板功能障碍，但仅见于血浆蛋白显著升高和免疫球蛋白水平高的患者，而17例无蛋白紊乱的患者中有3例血小板黏附和聚集正常。化疗以及血浆置换不仅使血浆中副蛋白水平降低，还使先前观察到的血小板功能障碍恢复正常。我们的实验证实了血浆中的M蛋白是多发性骨髓瘤中观察到的功能紊乱的原因这一观点。