人T细胞白血病病毒I型感染中抗磷酸酪氨酸抗体的出现及淋巴细胞蛋白的酪氨酸磷酸化
Appearance of antibodies against phosphotyrosine and tyrosine phosphorylation of lymphocyte proteins in human T cell leukemia virus type-I infection.
作者信息
Ogawa R, Koizumi T, Nakao Y, Sakitani M, Watanabe Y, Fujita T
机构信息
Department of Medicine, Kobe University School of Medicine, Hyogo.
出版信息
Jpn J Cancer Res. 1988 Mar;79(3):297-300. doi: 10.1111/j.1349-7006.1988.tb01589.x.
Abstract
Antibodies reactive with O-phosphotyrosine (Ptyr) were detected in all of 56 patients with adult T cell leukemia (ATL) with high titers ranging from 1:1,600 to 1:25,000 in 91% of the patients, whereas 97% of 70 healthy subjects showed titers of 1:400 or less. Ptyr-containing proteins (molecular weights of 70k, 45k and 30k) were detected in peripheral lymphocytes from patients with ATL. These proteins might be involved as antigens in the induction of such antibodies.
摘要
在56例成人T细胞白血病（ATL）患者中均检测到与O-磷酸酪氨酸（Ptyr）反应的抗体，91%的患者抗体效价较高，范围为1:1600至1:25000，而70名健康受试者中有97%的效价为1:400或更低。在ATL患者的外周淋巴细胞中检测到含Ptyr的蛋白质（分子量分别为70k、45k和30k）。这些蛋白质可能作为抗原参与此类抗体的诱导。
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Preparation and characterization of antibodies to O-phosphotyrosine and their use for identification of phosphotyrosine-containing proteins.抗O-磷酸酪氨酸抗体的制备、表征及其在含磷酸酪氨酸蛋白鉴定中的应用。
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Tyrosine phosphorylation of an interleukin 2 receptor-like protein in cells transformed by human T cell leukemia virus type I.人I型T细胞白血病病毒转化的细胞中一种白细胞介素2受体样蛋白的酪氨酸磷酸化
J Exp Med. 1987 Apr 1;165(4):959-69. doi: 10.1084/jem.165.4.959.
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Increase of phosphotyrosine-containing proteins in human carcinomas.
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