Suppr超能文献

聚乙烯醇/羟基磷灰石冷冻凝胶作为潜在人工软骨的力学性能

Mechanical properties of polyvinylalcohol/hydroxyapatite cryogel as potential artificial cartilage.

作者信息

Gonzalez Jimena S, Alvarez Vera A

机构信息

Composite Materials Group (CoMP), Research Institute of Material Science and Technology (INTEMA) (CONICET-UNMdP), Solís 7575, B7608FLC Mar del Plata, Argentina.

Composite Materials Group (CoMP), Research Institute of Material Science and Technology (INTEMA) (CONICET-UNMdP), Solís 7575, B7608FLC Mar del Plata, Argentina.

出版信息

J Mech Behav Biomed Mater. 2014 Jun;34:47-56. doi: 10.1016/j.jmbbm.2014.01.019. Epub 2014 Feb 2.

Abstract

The technological advances in material science are not enough to overcome the challenge of construct a material be able to replace the cartilage. The designed material has to meet the mechanical properties of cartilage and has to be also capable to be integrated with the articulation. Articular cartilage damage is a persistent and increasing problem which affects millions of people worldwide. Poly vinyl alcohol (PVA) hydrogels are promising implants, due to their similar properties as soft tissue; however their low mechanical resistance and durability together with its lack to integrate with the surrounding tissue restrict their application in this area. The poor adhesion can be solved by the development a composite hydrogel with bioactive and biocompatible filler, as hydroxyapatite (HA). The aim of this work was to obtain and characterize (physically, chemically and mechanically) PVA/HA composite hydrogels for potential application as articular replacement. Hence, composite hydrogels were prepared by adding of different amounts of HA in an aqueous solution of PVA and subsequent freezing-thawing cycles. It was observed that the addition of HA modified the physical and chemical features of the hydrogel and promoted the material crosslinking and stability. Moreover, it was found that the mechanical properties (compression, tension and nanoindentation) of the hydrogels were improved by the addition of HA. All these result indicate that these materials could be used as a potential cartilage replacement. However, further in vitro and in vivo studies are mandatory for future possible clinical applications and are actually being carried out.

摘要

材料科学的技术进步不足以克服构建能够替代软骨的材料这一挑战。设计的材料必须满足软骨的力学性能,并且还必须能够与关节整合。关节软骨损伤是一个持续且日益严重的问题,影响着全球数百万人。聚乙烯醇(PVA)水凝胶因其与软组织相似的特性而有望成为植入物;然而,它们的低机械抗性和耐久性以及与周围组织缺乏整合性限制了它们在该领域的应用。通过开发具有生物活性和生物相容性填料(如羟基磷灰石(HA))的复合水凝胶,可以解决粘附性差的问题。这项工作的目的是制备并表征(物理、化学和力学方面)PVA/HA复合水凝胶,以作为关节置换的潜在应用。因此,通过在PVA水溶液中添加不同量的HA并随后进行冻融循环来制备复合水凝胶。观察到添加HA改变了水凝胶的物理和化学特性,并促进了材料的交联和稳定性。此外,发现添加HA改善了水凝胶的力学性能(压缩、拉伸和纳米压痕)。所有这些结果表明,这些材料可作为潜在的软骨替代品。然而,未来可能的临床应用还需要进一步的体外和体内研究,目前正在进行这些研究。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验