自闭症谱系障碍患者对甜味的享乐反应完整无缺。
Intact Hedonic Responses to Sweet Tastes in Autism Spectrum Disorder.
作者信息
Damiano Cara R, Aloi Joseph, Burrus Caley, Garbutt James C, Kampov-Polevoy Alexei B, Dichter Gabriel S
机构信息
Department of Psychology, University of North Carolina at Chapel Hill, CB#3270, Davie Hall, Chapel Hill, NC, 27599-3270, USA.
Department of Psychology and Neuroscience, Duke University, Durham, NC 27705.
出版信息
Res Autism Spectr Disord. 2014 Mar;8(3):230-236. doi: 10.1016/j.rasd.2013.12.003.
The Sweet Taste Test (STT) is a standardized measure designed to index the ability to detect differences in sweet tastes (sweet taste sensitivity) and hedonic responses to sweet tastes (sweet taste liking). Profiles of response on the STT suggest enhanced hedonic responses to sweet tastes in psychiatric disorders characterized by dysfunctional reward processing systems, including binge-eating disorders and substance use disorders, and a putative mechanism governing STT responses is the brain opioid system. The present study examined STT responses in 20 adults with autism spectrum disorder (ASD) and 38 healthy control adults. There were no differences in sweet taste sensitivity or hedonic response to sweet tastes between the ASD and control groups. Within the ASD sample, ASD symptom severity was associated with sweet taste sensitivity, but not hedonic response to sweet taste. Results may ultimately shed light on brain opioid system functioning in ASD.
甜味测试（STT）是一种标准化测量方法，旨在评估检测甜味差异的能力（甜味敏感度）以及对甜味的享乐反应（对甜味的喜好）。STT的反应特征表明，在以奖赏处理系统功能失调为特征的精神疾病中，包括暴饮暴食症和物质使用障碍，对甜味的享乐反应增强，而控制STT反应的一个假定机制是脑阿片系统。本研究调查了20名患有自闭症谱系障碍（ASD）的成年人和38名健康对照成年人的STT反应。ASD组和对照组在甜味敏感度或对甜味的享乐反应方面没有差异。在ASD样本中，ASD症状严重程度与甜味敏感度相关，但与对甜味的享乐反应无关。研究结果最终可能会揭示ASD中脑阿片系统的功能。
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