使用分子印迹聚合物对映体对测定绝对构型。
Absolute configuration determination using enantiomeric pairs of molecularly imprinted polymers.
机构信息
Department of Chemistry, 232 Choppin Hall, Louisiana State University , Baton Rouge, Louisiana 70803, United States.
出版信息
Org Lett. 2014 Mar 7;16(5):1402-5. doi: 10.1021/ol500173y. Epub 2014 Feb 24.
A new method for determination of absolute configuration (AC) is demonstrated using an enantiomeric pair of molecularly imprinted polymers, referred to as "DuoMIPs". The ratio of HPLC capacity factors (k') for the analyte on each of the DuoMIPs is defined as the γ factor and can be used to determine AC when above 1.2. A mnemonic based on the complementary binding geometry of the DuoMIPs was used to aid in understanding and prediction of AC.
本文展示了一种使用对映体分子印迹聚合物（称为“DuoMIPs”）测定绝对构型（AC）的新方法。分析物在每个 DuoMIP 上的 HPLC 容量因子（k'）的比值定义为γ因子，当大于 1.2 时可用于确定 AC。本文使用了一种基于 DuoMIPs 互补结合几何形状的助记符来帮助理解和预测 AC。
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