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1996年和2007年荷兰普通人群中沙眼衣原体IgG血清阳性率：按性别和年龄的差异变化

Chlamydia trachomatis IgG seroprevalence in the general population of the Netherlands in 1996 and in 2007: differential changes by gender and age.

作者信息

van Aar F, de Moraes M, Morré S A, van Bergen J E A M, van der Klis F R M, Land J A, van der Sande M A B, van den Broek I V F

机构信息

Epidemiology & Surveillance Department, Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, The Netherlands Institute of Public Health Genomics, Department of Genetics and Cell Biology, Research Institute GROW, Faculty of Health, Medicine & Life Sciences, University of Maastricht, Maastricht, the Netherlands.

出版信息

Sex Transm Infect. 2014 Aug;90(5):434-40. doi: 10.1136/sextrans-2013-051074. Epub 2014 Feb 28.

DOI:10.1136/sextrans-2013-051074

PMID:24583966

Abstract

OBJECTIVES

Chlamydia trachomatis (CT) reporting rates from sexually transmitted infection clinics and general practitioners have shown a rising trend in the Netherlands. It is unknown to what extent this reflects increased CT transmission or improved case finding. To achieve more insight into the CT epidemic, we explored the CT IgG seroprevalence (a marker of past CT infection) in the general population of the Netherlands in 1996 and in 2007.

METHODS

From two population-based studies in 1996 and 2007, serum samples, demographic and sexual behaviour outcomes were examined, including 1246 men and 1930 women aged 15-39 years. Serum CT IgG antibodies were analysed using the Medac CT IgG ELISA test. Multivariate logistic regression analyses explored the seroprevalence and determinants over time.

RESULTS

The CT IgG seroprevalence was higher in women than in men (10% vs 6%). Among women aged 25-39 years the seroprevalence was lower in 2007 (9%) than in 1996 (14%; adjusted OR (aOR) 0.6, 95% CI 0.4 to 0.8). There was no statistical evidence of a difference in seroprevalence within birth cohorts. Factors associated with seropositivity were male gender (aOR 0.4, 95% CI 0.3 to 0.7), a self-reported history of CT infection (aOR 5.1, 95% CI 2.6 to 10.0), age 25-39 years (aOR 1.7, 95% CI 1.1 to 2.7), non-Western ethnicity (aOR 2.2, 95% CI 1.4 to 3.3) and ≥ 2 recent sexual partners (aOR 2.2, 95% CI 1.3 to 3.5).

CONCLUSIONS

Between 1996 and 2007 the proportion of individuals in the general population with CT IgG antibodies was lower among women aged 25-39 years, but remained similar among younger women and men.

摘要

目的

在荷兰，性传播感染诊所和全科医生报告的沙眼衣原体（CT）感染率呈上升趋势。目前尚不清楚这在多大程度上反映了CT传播的增加或病例发现的改善。为了更深入了解CT流行情况，我们调查了1996年和2007年荷兰普通人群中的CT IgG血清阳性率（过去CT感染的标志物）。

方法

从1996年和2007年两项基于人群的研究中，检测血清样本、人口统计学和性行为结果，包括1246名年龄在15 - 39岁的男性和1930名女性。使用Medac CT IgG ELISA检测法分析血清CT IgG抗体。多因素逻辑回归分析探讨了不同时间的血清阳性率及其决定因素。

结果

女性的CT IgG血清阳性率高于男性（10%对6%）。在25 - 39岁的女性中，2007年的血清阳性率（9%）低于1996年（14%；校正比值比（aOR）为0.6，95%可信区间为0.4至0.8）。在出生队列中，血清阳性率没有统计学差异的证据。与血清阳性相关的因素有男性（aOR 0.4，95%可信区间为0.3至0.7）、自我报告的CT感染史（aOR 5.1，95%可信区间为2.6至10.0）、年龄25 - 39岁（aOR 1.7，95%可信区间为1.1至2.7）、非西方族裔（aOR 2.2，95%可信区间为1.4至3.3）以及近期有≥2个性伴侣（aOR 2.2，95%可信区间为1.3至3.5）。