肥胖女性子女的人体测量学指标及双能X线吸收法测定的身体成分：一项随机对照试验的随访研究（孕期及子代生活方式[LiPO]研究）
Anthropometrics and body composition by dual energy X-ray in children of obese women: a follow-up of a randomized controlled trial (the Lifestyle in Pregnancy and Offspring [LiPO] study).
作者信息
Tanvig Mette, Vinter Christina A, Jørgensen Jan S, Wehberg Sonja, Ovesen Per G, Lamont Ronald F, Beck-Nielsen Henning, Christesen Henrik T, Jensen Dorte M
机构信息
Department of Endocrinology, Odense University Hospital, Odense, Denmark ; Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark ; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark ; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
出版信息
PLoS One. 2014 Feb 24;9(2):e89590. doi: 10.1371/journal.pone.0089590. eCollection 2014.
OBJECTIVE
In obese women, 1) to assess whether lower gestational weight gain (GWG) during pregnancy in the lifestyle intervention group of a randomized controlled trial (RCT) resulted in differences in offspring anthropometrics and body composition, and 2) to compare offspring outcomes to a reference group of children born to women with a normal Body Mass Index (BMI).
RESEARCH DESIGN AND METHODS
The LiPO (Lifestyle in Pregnancy and Offspring) study was an offspring follow-up of a RCT with 360 obese pregnant women with a lifestyle intervention during pregnancy including dietary advice, coaching and exercise. The trial was completed by 301 women who were eligible for follow-up. In addition, to the children from the RCT, a group of children born to women with a normal BMI were included as a reference group. At 2.8 (range 2.5-3.2) years, anthropometrics were measured in 157 children of the RCT mothers and in 97 reference group children with Body Mass Index (BMI) Z-score as a primary outcome. Body composition was estimated by Dual Energy X-ray (DEXA) in 123 successful scans out of 147 (84%).
RESULTS
No differences between randomized groups were seen in mean (95% C.I.) BMI Z-score (intervention group 0.06 [-0.17; 0.29] vs. controls -0.18 [-0.43; 0.05]), in the percentage of overweight or obese children (10.9% vs. 6.7%), in other anthropometrics, or in body composition values by DEXA. Outcomes between children from the RCT and the reference group children were not significantly different.
CONCLUSIONS
The RCT with lifestyle intervention in obese pregnant women did not result in any detectable effect on offspring anthropometrics or body composition by DEXA at 2.8 years of age. This may reflect the limited difference in GWG between intervention and control groups. Offspring of obese mothers from the RCT were comparable to offspring of mothers with a normal BMI.
目的
在肥胖女性中，1）评估随机对照试验（RCT）生活方式干预组孕期较低的孕期体重增加（GWG）是否会导致后代人体测量学指标和身体成分的差异，以及2）将后代结局与体重指数（BMI）正常的女性所生儿童的参考组进行比较。
研究设计与方法
LiPO（孕期及后代生活方式）研究是一项对360名肥胖孕妇进行的RCT的后代随访研究，这些孕妇在孕期接受了包括饮食建议、指导和运动在内的生活方式干预。该试验由301名符合随访条件的女性完成。此外，除了RCT中的儿童外，还纳入了一组BMI正常的女性所生的儿童作为参考组。在2.8岁（范围2.5 - 3.2岁）时，对157名RCT母亲的孩子和97名参考组孩子进行了人体测量，以体重指数（BMI）Z评分作为主要结局指标。在147次扫描中有123次（84%）成功通过双能X线吸收法（DEXA）估计了身体成分。
结果
随机分组之间在平均（95%可信区间）BMI Z评分（干预组0.06 [-0.17；0.29] vs. 对照组 -0.18 [-0.43；0.05]）、超重或肥胖儿童的百分比（10.9% vs. 6.7%）、其他人体测量学指标或DEXA测量的身体成分值方面均未观察到差异。RCT儿童与参考组儿童的结局没有显著差异。
结论
对肥胖孕妇进行生活方式干预的RCT在2.8岁时对后代人体测量学指标或DEXA测量的身体成分未产生任何可检测到的影响。这可能反映了干预组和对照组之间GWG的差异有限。RCT中肥胖母亲的后代与BMI正常母亲的后代相当。
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