Tan Zhuozhen, Wan Xiaolong, Zang Zhenhua, Qian Qun, Deng Wei, Gong Hegui
Department of Chemistry, Innovative Drug Research Center, and School of Materials Science and Engineering, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China.
Chem Commun (Camb). 2014 Apr 14;50(29):3827-30. doi: 10.1039/c3cc49859j. Epub 2014 Mar 4.
This work features first asymmetric Ni-catalyzed reductive coupling of allylic carbonates with aldehydes, which may proceed via allyl-Ni intermediates although Zn was used as the terminal reductant. Moderate to excellent enantiomeric excess was obtained with excellent functional group tolerance.
这项工作首次实现了镍催化的烯丙基碳酸酯与醛的不对称还原偶联反应，尽管使用锌作为末端还原剂，但该反应可能通过烯丙基镍中间体进行。反应获得了中等至优异的对映体过量，并且对官能团具有优异的耐受性。
