Ozmen Batuhan, Sükür Yavuz Emre, Atabekoğlu Cem, Güngör Mete
University of Ankara, Department of Obstetrics and Gynecology, Ankara, Trurkey.
J Turk Ger Gynecol Assoc. 2009 Sep 1;10(3):175-7. eCollection 2009.
Metastasis to the incision site of squamous cervical cancer (SCC) is an extremely rare entity which is strictly related with extremely poor prognosis. The vast majority of the reported cases died in a year due to distant recurrences, whereby skin metastases were predominantly observed close to the primary tumor site. A SCC with skin metastasis which was diagnosed 5 years after the radical surgery and postoperative radiotherapy which involved the midline incision site was reported. Large surgical excision of the metastasis with remaining surgical free margins (>2 cm) and combined chemo-radiotherapy with single agent (cisplatinum) was performed. The patient did not show any recurrences for 4 years follow-up. Apparently, palliative combined chemo-radiotherapy along with large excision seems favorable for controlling symptoms and progression of skin metastasis of squamous cervical cancer.
宫颈鳞状细胞癌(SCC)转移至手术切口部位是一种极为罕见的情况,与极差的预后密切相关。绝大多数报道的病例在一年内因远处复发而死亡,其中皮肤转移主要见于原发肿瘤部位附近。本文报道了1例在根治性手术及术后放疗后5年,于中线手术切口部位诊断为伴有皮肤转移的SCC。对转移灶进行了大范围手术切除,切缘阴性(>2 cm),并采用单药(顺铂)联合放化疗。该患者在4年的随访中未出现任何复发。显然,姑息性联合放化疗及大范围切除似乎有利于控制宫颈鳞状细胞癌皮肤转移的症状及病情进展。