Safarzade Alireza, Talebi-Garakani Elahe
Department of Exercise Physiology, Faculty of Physical Education & Sport Science, University of Mazandaran, Babolsar, Iran.
J Diabetes Metab Disord. 2014 Mar 4;13(1):41. doi: 10.1186/2251-6581-13-41.
Type 1 diabetes mellitus is associated with a high risk for early atherosclerotic complications. Altered lipids and lipoprotein metabolism in chronic diabetes mellitus is associated with pathogenesis of atherosclerosis and other cardiovascular diseases. The aim of this study was to investigate the effects of 4 weeks resistance training on plasma lipid profile, fatty acid binding protein (FABP) 4 and apolipoprotein (apo) A-I levels in type 1 diabetic rats.
Thirty two male Wister rats (12-14 weeks old) were randomly divided into four groups: non-diabetic control; non-diabetic trained; diabetic control; diabetic trained. The rats in training groups were subjected to a resistance training program (3 days/wk, for 4 wk) consisted of climbing a ladder carrying a load suspended from the tail.
Diabetic inducing increased plasma apoA-I and decreased FABP4 levels compared with non-diabetic control group (respectively, P = 0.001 & P = 0.041). After 4 weeks' resistance training, plasma levels of apoA-I and FABP4 in the diabetic trained rats were significantly higher compared with the diabetic control group (respectively, P = 0.003 & P = 0.017). Plasma HDL-C level in diabetic trained group was higher than diabetic control group (P = 0.048). Liver triglycerides concentrations were significantly lower in both trained (non-diabetic and diabetic) groups compared with their control groups (respectively, P = 0.041 and P = 0.002).
These data indicated that resistance training may be an efficient intervention strategy to increase plasma apoA-I, HDL-C and FABP4 concentrations, along with decreases liver triglycerides in streptozotocin induced diabetic rats. Further research is needed to elucidate physiological significance of circulating FABP4 levels.
1型糖尿病与早期动脉粥样硬化并发症的高风险相关。慢性糖尿病中脂质和脂蛋白代谢的改变与动脉粥样硬化及其他心血管疾病的发病机制有关。本研究的目的是调查4周抗阻训练对1型糖尿病大鼠血浆脂质谱、脂肪酸结合蛋白（FABP）4和载脂蛋白（apo）A-I水平的影响。
32只雄性Wister大鼠（12 - 14周龄）被随机分为四组：非糖尿病对照组；非糖尿病训练组；糖尿病对照组；糖尿病训练组。训练组的大鼠接受一项抗阻训练计划（每周3天，共4周），该计划包括攀爬一个悬挂着从尾巴上吊着的重物的梯子。
与非糖尿病对照组相比，糖尿病诱导使血浆apoA-I增加，FABP4水平降低（分别为P = 0.001和P = 0.041）。经过4周的抗阻训练后，糖尿病训练组大鼠的血浆apoA-I和FABP4水平显著高于糖尿病对照组（分别为P = 0.003和P = 0.017）。糖尿病训练组的血浆高密度脂蛋白胆固醇（HDL-C）水平高于糖尿病对照组（P = 0.048）。与各自的对照组相比，两个训练组（非糖尿病和糖尿病）的肝脏甘油三酯浓度均显著降低（分别为P = 0.041和P = 0.002）。
这些数据表明，抗阻训练可能是一种有效的干预策略，可增加链脲佐菌素诱导的糖尿病大鼠的血浆apoA-I、HDL-C和FABP4浓度，同时降低肝脏甘油三酯。需要进一步研究以阐明循环FABP4水平的生理意义。
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