一种从箭毒木种子中提取的新的杠柳毒苷元强心苷。

A new periplogenin cardenolide from the seeds of Antiaris toxicaria.

作者信息

Wu Xiu-Li, Wu Yu-Ling, Li Hou-Gang, Liu He-Tao, Fu Xue-Yan, Cui Rui-Qin, Wang Jian-Huan, Liu Cheng, Chen Jing

机构信息

a College of Pharmacy, Ningxia Medical University , Yinchuan 750004 , China.

出版信息

J Asian Nat Prod Res. 2014;16(4):418-21. doi: 10.1080/10286020.2014.885506.

DOI:10.1080/10286020.2014.885506

PMID:24597720

Abstract

A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria. The structure of the new compound was characterized as periplogenin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (1) by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectrometry, and the known compounds were identified by comparison of their NMR and HR-TOF-MS data with those reported in the literature. Compound 1 showed significant cytotoxicity against Hela and HepG-2 cell lines.

摘要

从见血封喉种子中分离得到一种新的杠柳毒苷元强心苷，即见血封喉苷（1），以及三种已知的强心苷。通过一维和二维核磁共振、高分辨飞行时间质谱和圆二色光谱等光谱方法，将新化合物的结构表征为杠柳毒苷元-3-O-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃葡萄糖苷（1），并通过将其核磁共振和高分辨飞行时间质谱数据与文献报道的数据进行比较，鉴定出了已知化合物。化合物1对Hela和HepG-2细胞系显示出显著的细胞毒性。