钯催化吲哚与环己酮的直接芳基化反应。
Palladium-catalyzed direct arylation of indoles with cyclohexanones.
机构信息
Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University , Xiangtan 411105, China.
出版信息
Org Lett. 2014 Mar 21;16(6):1618-21. doi: 10.1021/ol500231c. Epub 2014 Mar 5.
PMID:24597845
Abstract
A novel palladium catalyzed approach to 3-arylindoles was developed from indoles and cyclohexanones. Various cyclohexanones acted as aryl sources via an alkylation and dehydrogenation sequence using molecular oxygen as the hydrogen acceptor. This method showed good regioselectivity and afforded 3-arylindoles as the sole products.
摘要
开发了一种新型钯催化的 3-芳基吲哚方法，该方法由吲哚和环己酮合成。各种环己酮通过使用分子氧作为氢受体的烷基化和脱氢序列作为芳基源。该方法表现出良好的区域选择性，仅得到 3-芳基吲哚作为产物。
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