结直肠癌的术中腹腔灌洗
Intra-operative peritoneal lavage for colorectal cancer.
作者信息
Passot Guillaume, Mohkam Kayvan, Cotte Eddy, Glehen Olivier
机构信息
Guillaume Passot, Kayvan Mohkam, Eddy Cotte, Olivier Glehen, Departement of General and Surgical Oncology, Hospices Civils de Lyon, 69495 Pierre Bénite, France.
出版信息
World J Gastroenterol. 2014 Feb 28;20(8):1935-9. doi: 10.3748/wjg.v20.i8.1935.
Abstract
Free cancer cells can be detected in peritoneal fluid at the time of colorectal surgery. Peritoneal lavage in colorectal surgery for cancer is not used in routine, and the prognostic significance of intraperitoneal free cancer cells (IPCC) remains unclear. Data concerning the technique of peritoneal lavage to detect IPCC and its timing regarding colorectal resection are scarce. However, positive IPCC might be the first step of peritoneal spread in colorectal cancers, which could lead to early specific treatments. Because of the important heterogeneity of IPCC determination in reported studies, no treatment have been proposed to patients with positive IPCC. Herein, we provide an overview of IPCC detection and its impact on recurrence and survival, and we suggest further multi-institutional studies to evaluate new treatment strategies.
摘要
在结直肠癌手术时，可在腹腔积液中检测到游离癌细胞。结直肠癌手术中的腹腔灌洗并非常规操作，腹腔内游离癌细胞（IPCC）的预后意义仍不明确。关于检测IPCC的腹腔灌洗技术及其与结直肠切除术时机的相关数据稀缺。然而，IPCC阳性可能是结直肠癌腹膜播散的第一步，这可能促使早期进行针对性治疗。由于已报道研究中IPCC检测存在重要的异质性，对于IPCC阳性的患者尚未提出治疗方案。在此，我们概述了IPCC检测及其对复发和生存的影响，并建议开展进一步的多机构研究以评估新的治疗策略。
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本文引用的文献
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