Pedersen A B, Mehnert F, Havelin L I, Furnes O, Herberts P, Kärrholm J, Garellick G, Mäkela K, Eskelinen A, Overgaard S
Competence Centre for Clinical Epidemiology and Biostatistics, North, Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Osteoarthritis Cartilage. 2014 May;22(5):659-67. doi: 10.1016/j.joca.2014.03.005. Epub 2014 Mar 13.
To evaluate implant survival following primary total hip replacement (THR) in younger patients. To describe the diversity in use of cup-stem implant combinations.
29,558 primary THRs osteoarthritis (OA) patients younger than 55 years of age performed from 1995 through 2011 were identified using the Nordic Arthroplasty Registry Association database. We estimated adjusted relative risk (aRR) of revision with 95% confidence interval (CI) using Cox regression.
In general, no difference was observed between uncemented and cemented implants in terms of risk of any revision. Hybrid implants were associated with higher risk of any revision (aRR = 1.3, CI: 1.1-1.5). Uncemented implants led to a reduced risk of revision due to aseptic loosening (aRR = 0.5, CI: 0.5-0.6), whereas the risk was similar for hybrid and cemented implants. Compared with cemented implants, both uncemented and hybrid implants led to elevated risk of revision due to other causes, as well as elevated risk of revision due to any reason within 2 years. 183 different uncemented cup-stem implant combinations were registered in Denmark, of these, 172 were used in less than 100 operations which is similar to Norway, Sweden and Finland.
Uncemented implants perform better in relation to long-term risk of aseptic loosening, whereas both uncemented and hybrid rather than cemented implants in patients younger than 55 years had more short-term revisions because problems due to dislocation, periprosthetic fracture and infection has not yet been completely solved. The vast majority of cup-stem combinations were used in very few operations.
评估年轻患者初次全髋关节置换术(THR)后的植入物存活率。描述髋臼柄植入物组合使用的多样性。
利用北欧关节置换登记协会数据库,确定了1995年至2011年期间进行的29558例年龄小于55岁的原发性全髋关节置换术骨关节炎(OA)患者。我们使用Cox回归估计了翻修的调整相对风险(aRR)及其95%置信区间(CI)。
总体而言,在任何翻修风险方面,非骨水泥型和骨水泥型植入物之间未观察到差异。混合型植入物与任何翻修的较高风险相关(aRR = 1.3,CI:1.1 - 1.5)。非骨水泥型植入物降低了因无菌性松动导致的翻修风险(aRR = 0.5,CI:0.5 - 0.6),而混合型和骨水泥型植入物的风险相似。与骨水泥型植入物相比,非骨水泥型和混合型植入物均导致因其他原因导致的翻修风险升高,以及2年内因任何原因导致的翻修风险升高。丹麦登记了183种不同的非骨水泥髋臼柄植入物组合,其中172种用于少于100例手术,挪威、瑞典和芬兰的情况类似。
非骨水泥型植入物在无菌性松动的长期风险方面表现更好,而在55岁以下患者中,非骨水泥型和混合型而非骨水泥型植入物有更多短期翻修,因为脱位、假体周围骨折和感染等问题尚未完全解决。绝大多数髋臼柄组合使用的手术例数很少。