Borsook D, Erpelding N, Lebel A, Linnman C, Veggeberg R, Grant P E, Buettner C, Becerra L, Burstein R
Boston Children's Hospital P.A.I.N. Group, Boston Children's Hospital, USA; Massachusestts General Hospital, Boston Children's Hospital, USA; Harvard Medical School, USA.
Boston Children's Hospital P.A.I.N. Group, Boston Children's Hospital, USA; Harvard Medical School, USA.
Neurobiol Dis. 2014 Aug;68:200-14. doi: 10.1016/j.nbd.2014.03.008. Epub 2014 Mar 21.
The brain responds differently to environmental and internal signals that relate to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point of migraine. The cyclic surges of gonadal hormones may directly alter neuronal, glial and astrocyte function throughout the brain. Estrogen is mainly excitatory and progesterone inhibitory on brain neuronal systems. These changes contribute to the allostatic load of the migraine condition that most notably starts at puberty in girls.
大脑对与神经系统发育阶段相关的环境和内部信号有不同的反应。虽然遗传和表观遗传因素会导致疾病前状态,但女性体内的激素波动可能会改变偏头痛的阈值。性腺激素的周期性激增可能会直接改变整个大脑中神经元、神经胶质细胞和星形胶质细胞的功能。雌激素对大脑神经元系统主要起兴奋作用,而孕激素则起抑制作用。这些变化导致了偏头痛状况的适应性负荷增加,这种情况在女孩青春期最为明显。